The Spaniard was in charge of the Londoners for less than a year despite guiding them to Capital One Cup success, and he will have target Yevhen Konoplyanka in his ranks
The Spaniard managed Tottenham between 2007 and 2008, leading them to a Capital One Cup title before being sacked the following season with the London club rock bottom of the Premier League.
|7/2||Tottenham are 7/2 with Paddy Power to beat Dnipro to nil|
Dnipro, who have not played a competitive game since December because of the mid-season break in Ukraine, are enjoying a strong season in both domestic and European competition, sitting fourth in the league table and having qualified for the knockout stages of the Europa League after finishing second behind Fiorentina in Group E.
And they can call upon Ukraine winger Yevhen Konoplyanka, who was the subject of a failed approach from Liverpool in the January transfer window and has vowed to help his club beat Spurs.
The London club had also shown an interest in Konoplyanka before pulling out of the race on the advice of manager Tim Sherwood.
However, it is Spurs who will approach the first competitive meeting between the two sides as favourites following a resurgence under new boss Sherwood.
Tottenham have lost just three of the 12 games since the dismissal of Andre Villas-Boas in December, with Sherwood reinvigorating a side whose hopes of reaching next season's Champions League had looked to be fading.
The London club are only three points behind Liverpool in the race for fourth place in the Premier League, but they will now switch focus to the Europa League as they seek to improve the club's haul of two Uefa Cups, as the competition was formerly known.
And, although Tottenham visit Norwich City in the league on Sunday, Sherwood insists that the club have the resources to cope with the fixture congestion.
"I love [the Europa League]," Sherwood said. "There are a lot of games coming up but we haven't got to worry about that.
"We're out of the rest of the [cup] competitions and we've got a big enough squad here to cope.
"There will be opportunities for other people to play because the games will come thick and fast and you're playing on Thursday and Sunday."
Tottenham still have a number of injury concerns going into the game, with midfielders Sandro (calf) and Gylfi Sigurdsson (thigh) both doubts.
Sherwood also confirmed that Younes Kaboul, Emmanuel Adebayor, Kyle Walker, Hugo Lloris and Aaron Lennon have not traveled with the Spurs squad.
Erik Lamela (thigh) remains on the sidelines, along with defender Vlad Chiriches (back).
Dnipro, meanwhile, will look to the likes of Konoplyanka and strikers Roman Zozulya and Yevhen Seleznyov to help guide them to a shock triumph.