Alan Pardew's side have suffered successive 3-2 defeats, while the newly promoted side will be hoping to record back-to-back Premier League victories for the first time
The north-east side head into the clash having won their last six meetings with the Welsh outfit in all competitions.
However, while Newcastle have the better historical record, Alan Pardew's men will be seeking a response after a recent dip in their Premier League form, having suffered back-to-back defeats.
They sit in 16th in the table after successive 3-2 defeats against both Hull City and Everton, with the latter game in particular highlighting their defensive frailties.
Newcastle found themselves three goals down by the break at Goodison Park on Monday and, despite a second-half fightback, they were powerless to prevent their third defeat of the season.
Now Pardew wants his side to repeat their second-half showing over the entirety of the game when they face Malky Mackay's men on Saturday.
"It's about 90 minutes of a consistent performance," he told The Chronicle.
"That's what this team needs to bring to the party. Like we did at Aston Villa and like we did at home to Fulham."
Loic Remy could continue up-front for Pardew after scoring three times in Newcastle's last two Premier League outings, with Papiss Cisse's goal drought now stretching to 12 league matches.
Meanwhile, Jonas Gutierrez may make his return from a hamstring injury while Yohan Cabaye is likely to start in midfield, after an impressive substitute appearance on Monday.
Cardiff picked up their second Premier League victory of the season last time out with a 2-1 win over Fulham, with Jordon Mutch scoring a late winner.
That was Cardiff's first away league victory of the season and Mackay will also be keen for his side to continue their impressive home form.
While they have failed to score in their last two games at the Cardiff City Stadium, last season's Championship winners have lost just three of 26 home games in the league since the start of the 2012-13 campaign.
Mackay's only injury doubt is Andreas Cornelius (ankle), who has not played since the League Cup win over Accrington Stanley in August.