The in-form Schwarzgelben face a tricky trip to Borussia-Park as they look to hold on to top spot in the Bundesliga
The Bundesliga leaders have not lost to die Fohlen in their last four league clashes, with 5-0 and 2-0 victories in 2012 sandwiched by 1-1 draws.
Dortmund will come into the game as favourites, having dropped points only once in the league this season, as well as having been boosted by a 3-0 win over Marseille in the Champions League on Tuesday.
Jurgen Klopp's men have scored 10 goals in their last three games and have also kept clean sheets in all of them, with their only defeat this term having come in Europe, against Napoli.
Last season's Bundesliga runners-up have also been in fine scoring form, hitting 21 goals in their seven league matches, with Robert Lewandowski one of four players at the top of the scoring charts.
However, Dortmund's only dropped points in the league came on the road and on Saturday they face a Monchengladbach side with an impressive record at Borussia-Park.
Lucien Favre's men have won all three games at home in the league this season, scoring 11 goals in the process, while conceding just twice.
Favre has also been boosted by the news that leading scorer Max Kruse is likely to be fit for the visit of Klopp's charges despite fears over a bruised shoulder.
He has four goals in the German top flight this season and Monchengladbach's cause has also been helped by the form of Brazilian forward Raffael, who has four to his name.
The latter is looking forward to facing one of the most respected and admired sides in the game right now.
"They're one of the best teams in the world and I think it's important to play teams like that," he said. "Everyone wants to play against a team like Dortmund.
"As far as we're concerned, we're working hard to deliver a good season. We've got to put ourselves in a good position come the end of the season. Then we'll see what's possible."