The visitors beat Jurgen Klopp's side 2-0 earlier this season but are without a victory since the winter break while their hosts have won three on the bounce in all competitions
Borussia Monchengladbach will hope positive off-field news is translated into a first Bundesliga win of the year against Borussia Dortmund.
Saturday's visitors to Signal Iduna Park have been boosted by the agreement of a contract extension with coach Lucien Favre and the Swiss will hope to celebrate that deal with a first competitive win since the mid-season break.
Favre also completed the signing of Basel goalkeeper Yann Sommer this week - as a replacement the outgoing Marc-Andre ter Stegen - and he will be praying that his players are lifted by such encouraging news.
Indeed, Gladbach have taken just three points from a possible 21 since the season resumed at the tail end of January and have slipped to eighth after what had been a promising start to their campaign.
They have not won on the road in the top flight since November but have two main reasons to be hopeful ahead of their trip to Dortmund - primarily the form of Brazilian striker Raffael.
As well as having 12 Bundesliga goals to his name this season, he has found the net in three of his last four outings.
Favre's charges will also take heart from their last meeting with Jurgen Klopp's side, when they ran out 2-0 winners at Borussia-Park.
Since then, Dortmund have seen Bayern Munich all but wrap up the title - although they will remain eager to tie up second place, thus allowing them to focus on their bid to win both the DFB-Pokal and the Champions League.
While leading goalscorer Robert Lewandowski may not be risked ahead of their European tie against Zenit St Petersburg on Wednesday due to a knee problem, Klopp's men might be able to do without their star striker.
Dortmund have won four of their last five top-flight matches, scoring 13 goals and conceding just once in those victories, with the 3-0 defeat to Hamburg their only slip-up of late.