Roma: Doni; N. Burdisso, Juan, Mexes, Riise; Pizarro, De Rossi, Taddei, Perrotta, Vucinic; Totti.
DID YOU KNOW?
Shakhtar scored three goals in a 13-minute span in the first leg in Rome.
The Miners have never lost at the Donbass Arena since it opened in 2009.
Oleksandr Kucher will miss the match with a knee injury.
Roma have not lost a match since Vincenzo Montella replaced Claudio Ranieri two weeks ago.
Marco Cassetti and Jeremy Menez are suspended for the second leg in Ukraine.
Roma needed a last minute penalty to down Lecce last Friday.
February 16, 2011: Roma 2-3 Shakhtar Donetsk
Roma took an early lead thanks to a Razvan Rat own goal before Shakhtar stormed back with a triple salvo during a 13-minute span in the first half. Jeremy Menez cut the deficit in half with a goal in the second half but it was too little, too late for Roma.
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The 23-year-old leads the team with four goals in the current Champions League campaign and will be eager to add to his personal tally against a leaky Roma backline. Scored in the first leg and is a favourite to find the back of the net again on Tuesday evening.
The Norway full-back will be keen to atone for his crucial mistake against Shakhtar in the first leg. Goals will be the order of the day for Roma so he will need to push forward at every opportunity and cause problems for the Ukrainian side out wide.
The Donbass Arena is a fortress where Shakhtar have won their last 18 competitive matches and Roma don't have the collective strength to break the Miners' impressive streak. The hosts play the Serie A side off the park on Tuesday night.