AC Milan host Ajax on Wednesday in a Champions League showdown to decide who will join Group H leaders Barcelona in the knockout stages.
The home side currently sit two points behind the Catalans and could win the pool should the Spanish champions lose at home against the already-eliminated Celtic.
Ajax, meanwhile, are three points off the top, but cannot climb above Barcelona due to their inferior head-to-head record. However, they will be hoping to avoid conceding their 200th European Cup goal as they go in search of the three points they need to reach the last 16 at the Rossoneri's expense.
The Amsterdam outfit came close to a home win against Milan on matchday two, taking a 90th-minute lead through Stefano Denswil before Mario Balotelli equalised from the spot in the fourth minute of stoppage time.
Frank de Boer's men have not won any of their last six away fixtures in the Champions League, dating back to a 2-0 success at Dinamo Zagreb in October 2011, but are unbeaten in their last three matches in Italy.
Milan ended a run of seven games without a win in all competitions when they cruised to a 3-0 win at Celtic last time out, scoring their 600th goal in competition in the process.
After a dismal start to the domestic season, Massimiliano Allegri's side are now unbeaten in four Serie A matches and appear to have turned a corner.
Their Dutch opponents defeated Barcelona 2-1 on matchday five in one of their biggest European results in recent years, and have won their last four matches in the Eredivisie, leaving them second behind Vitesse.
The four-time European Cup winners won 4-0 against NAC Breda in their most recent domestic fixture, and were victorious on their last visit to San Siro, when they ran out 2-0 winners in the 2010-11 Champions League group stages.
Marco Amelia (knee) is expected to be out until the new year, while Mattia De Sciglio (knee), who has made only one appearance since August, is among a number of injury doubts for Milan. Giampaolo Pazzini (knee) is a long-term absentee. Robinho is not expected to be back until the end of the year.
Ajax, meanwhile, are without their captain Siem de Jong and defender Nicolai Boilsen, who have both picked up hamstring injuries. Lerin Duarte also has ankle problems, while Joel Veltman is suspended.
However, they welcome back Icelandic striker Kolbeinn Sigthorsson, who has recovered from an ankle injury he sustained in Iceland's World Cup play-off clash against Croatia.