The north London outfit face a 4,000-mile round trip as they target a place in the group stages of Europe's second-tier club competition and will be without Gareth Bale once again
After narrowly missing out on qualification for the Champions League last season, Villas-Boas's men are fighting for their place in Europe's second-tier club competition - and they begin their campaign with a 2,000-mile trip to Georgia for the first leg of their play-off tie.
Tottenham have a rich history in Europe, having won the inaugural edition of what was then known as the Uefa Cup back in 1972 before going on to taste success again in 1984.
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Dinamo's finest hour in European competition arguably came in 1981, when they lifted the Cup Winners' Cup for the first and only time in their history.
These two teams have actually met before in the Uefa Cup, having been drawn together in the group stages of the 1973-74 edition.
They shared a 1-1 draw in Georgia in the first meeting before Tottenham ran out 5-1 winners at White Hart Lane in the return thanks to doubles from Martin Chivers and Martin Peters and a further goal from Chris McGrath.
Ahead of this year's meeting, Spurs have few injury worries - although they remain without the services of winger Gareth Bale.
The Welshman has officially been sidelined by a foot injury, although talk a proposed world-record move to Real Madrid refuses to go away.
Tottenham have enjoyed a productive transfer window and they will be able to call on new signings Nacer Chadli and Roberto Soldado in attack in Bale's absence.
For Georgian Premier League champions Dinamo, meanwhile, their biggest threat comes in the form of Spanish striker Xisco, who netted 22 goals to finish as the Georgian top flight's leading scorer last term.