The Germany international striker netted once in each half after a fine opener from Aaron Ramsey as Arsene Wenger's men remained on course for Champions League qualification
In a dress rehearsal for the FA Cup final between these teams in May, the Gunners were comfortable victors in a physical Premier League encounter, with Lukas Podolski scoring twice.
After Aaron Ramsey finished off a fine attacking move to sweep home half an hour into the game, the German netted once in each half to cap off a solid afternoon's work for Arsene Wenger's men.
Nikica Jelavic and Podolski went close after a quiet opening 15 minutes but both were denied by good saves.
|VIEW FROM THE KC
|By Peter Staunton
It could not have gone any better here for Arsene Wenger. Three points which aid their Champions League quest and they absolutely showed that they had the measure of Hull City ahead of the FA Cup final.
Aaron Ramsey was imperious on his first start since returning from injury while Mesut Ozil was also lively. The Arsenal goals were top-class and, aside from very rare exceptions, they had the hosts at arm's length.
This is the type of fixture in which Arsenal might have struggled during the season's earlier rough spell but there were no troubles here. A comprehensive, dominant display.
Hull went agonisingly close to levelling four minutes later as Jake Livermore picked up a loose ball and unleashed a long-range strike that beat Wojciech Szczesny but struck the post before bouncing to safety.
Arsenal doubled their lead in first-half stoppage time through Podolski, although a cluster of Hull players felt that Jelavic had been fouled by Mikel Arteta in the build-up. The German timed his run into the penalty area perfectly to lash home after Ramsey had cushioned Giroud's cross on his chest.
Wenger's side made it 3-0 nine minutes after the break. Cazorla teed up Ramsey on the edge of the area and the midfielder's effort was saved by Harper with his feet but the ball fell to Podolski and he calmly fired home from seven yards.
The visitors were very nearly gifted a fourth in the 64th minute as Harper misjudged a backpass from James Chester. Giroud blocked the goalkeeper's clearance and struck the crossbar from a tight angle.
Mertesacker was next to go close as he met a 75th-minute free kick from Cazorla but his looping header was just too high.
Ramsey missed a late chance to net his second but it did not matter as Arsenal completed a comfortable win over their FA Cup final opponents and took another step towards securing Champions League football for next season.