The Spain international has been sidelined until December giving record signing Wilfried Bony a chance to shine, while the hosts are looking to escape the relegation zone
The Spaniard, who picked up the injury in the Swans' 1-0 defeat against south Wales rivals Cardiff, is expected to return for the club's clash with Newcastle on December 4.
In the meantime, record signing Wilfried Bony, who had reason to celebrate this week as the Ivory Coast booked their place at the World Cup, is likely to resume up front, having netted three goals in his last two outings for Swansea.
Fulham, meanwhile, will get a first taste of what they can expect from newly-appointed head coach Rene Meulensteen.
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The side have yet to net more than twice in a league match this season, while Dimitar Berbatov - who netted 15 times last year - has just one goal in 10 appearances this time around.
Fulham have made a poor start to the Premier League season and sit 18th after just three wins in their first 11 matches, though they can leapfrog Swansea with a win.
New Fulham owner Shahid Khan is hoping the expertise of Meulensteen – a coach at Manchester United between 2001 and 2006 and then Sir Alex Ferguson's assistant at Old Trafford from 2007 to 2013 – can help Jol as he seeks an upturn in fortunes.
Another priority for the Dutch duo will be improving Fulham's leaky defence as the Craven Cottage outfit have shipped 11 goals in their last three matches.
Several of Fulham's players were involved in international action over the last week, and Greece captain Giorgos Karagounis led his side to victory in their World Cup play-off against Romania.
Sweden's Alexander Kacaniklic was not so lucky, though, as his side lost 4-2 on aggregate to Portugal.
Defender Brede Hangeland is a doubt with a nerve problem in his leg, while Hugo Rodallega (groin), Sascha Riether (suspension) and Matthew Briggs (hernia) will certainly miss out for Fulham.
Combining domestic and continental commitments has proved a challenge this season for Swansea, who are 13th but just two points above the relegation zone.
They have not won in over a month and will enter Saturday's fixture with just two triumphs since September 22.
Swansea goalkeeper Michel Vorm will return from suspension but Michu (ankle), Pablo Hernandez (thigh) and Garry Monk (knee) are all still sidelined.