Schalke was able to advance to the knockout stage with a 2-0 win over Basel on the final matchday, and after finishing second in the group it faces a tough Real Madrid side.
Schalke was the lowest scoring squad of all teams in the Champions League to advance, with six goals scored during the group stage.
The Germans are heavy underdogs on Wednesday, with William Hill pegging them at 7.00 to win outright. The double chance (a Schalke win or draw) still presents value with an offering of 2.50.
They are currently fourth in the German table and are coming off a 0-0 result to Mainz last week. Though they are unbeaten in their previous eight matches in German competition, they are suffering from a series of injuries today.
Taking Schalke is going to be hard knowing that Madrid will see the return of Cristiano Ronaldo to the lineup after serving a three-game suspension in La Liga.
The Portuguese superstar is never offered above evens in the correct goal scorer markets due to his high potency up front, which is evidenced by his record nine goals during the group stage. Today he is listed at 1.40 to strike the back of the net.
If Gareth Bale is inserted into the lineup, consider him at 1.91 as he has been solid as of late.
Real Madrid is listed right now at 1.44 to take a win, and 2.10 for the halftime/fulltime pick. The Spanish giant went undefeated during the group stage with a 5-0-1 record, and was 2-0-1 on the road, averaging just over three goals scored while away from the Bernabeu.
Los Blancos are undefeated in their last 27 games, an impressive feat that without question has the team riding a high wave of confidence. As much gusto as bettors are having with Madrid today, one scary stat to ponder is that they have only one win from their last 25 matches when playing in Germany.
A draw pick is available at 4.33, though I expect an outright winner in this one and it will more than likely be the Spaniards coming out on top.