The Real Madrid forward has been ruled out for Friday night's pre-World Cup friendly in Foxborough, Massachusetts.
The Portuguese Football Federation announced Thursday that the forward has been ruled out for Friday night's pre-World Cup friendly in Foxborough, Massachusetts, with tendinitis in his left leg and a left leg muscle injury.
Raul Meireles and Pepe will also miss the second-to-last friendly for Portugal before the team heads to Brazil. The Seleccao will face Ireland in New Jersey on Tuesday.
Ronaldo led Madrid to the Champions League title last month despite being bothered by leg injuries late in the season.
Portugal will face the United States, Germany and Ghana in the 'Group of Death' in Brazil. The nation opens its World Cup schedule against the Germans on June 16.
Mexico, meanwhile, has one more friendly left before facing Cameroon on June 13. El Tri will hope to bounce back from Tuesday's poor showing against Bosnia.