Calero was been pronounced dead in a Mexico City hospital after days of treatment after suffering an apparent cerebral thrombosis at his home in Pachuca, Mexico.
Calero, who spent most of his playing career with Pachuca in the Mexican league, had been hospitalized since Nov. 28 after thrombosis in his arm caused a blood clot to reach his brain. He was later placed on life support.
"Miguel Calero was a football player who left his mark on a great era in the history of Club Pachuca," the team said in a statement.
Calero retired as a player from the Mexican league on Sept. 29, 2011 after suffering a venous thrombosis in his left arm. With Pachuca, he won three titles. He played for the Colombian national team from 1995-2007.