Reports claimed the Potters were moving in on the New England Revolution and USA striker, and the Stoke City boss says the club is "hopeful" of concluding a deal.
The 20-year-old has been linked with a move to the Potters throughout the transfer window, with Soccer By Ives reporting that the United States international has already signed a pre-contract agreement to join the club when his current deal at New England expires in December.
Hughes himself has confirmed the club is interested in bringing Agudelo to the Britannia Stadium, and the manager hopes to conclude a deal for the forward. Should Agudelo join Stoke, he would be the latest American addition to a squad that already employs U.S. internationals Geoff Cameron, Brek Shea and Maurice Edu.
"We are hopeful of progressing that," Hughes told The Sentinel. "There seems to be a willingness from most sides.
"He's a good young player and we feel he's got potential, and we would like that to happen."
Hughes is looking for further additions to his squad before the transfer window closes and has already completed deals for the likes of Erik Pieters and Marc Muniesa, with the club said to be interested in Hannover striker Mame Biram Diouf as well.