Jose Angel Sanchez has revealed the forward will likely move on before next season, with two strikers to be signed to complement Karim Benzema.
The Argentine striker was coy to reporters when asked about his future at the club early last month, amid suggestions that president Florentino Perez is unconvinced by his form this season. Sanchez has now indicated the 25-year-old will be sold to allow room for two more forwards to join Karim Benzema at Santiago Bernabeu.
Higuain has scored 15 goals in 38 appearances in all competitions for Los Blancos this season.
"In a big club like Real Madrid, it is assumed there is space for two or three high-level No.9s. It was Benzema and Higuain. Higuain will go, Benzema will stay, and two others will arrive," Sanchez told Le 10 Sport.
Madrid has been linked with a move for Manchester City striker Sergio Aguero throughout the current campaign, while it continues to be linked with a big-money bid for Tottenham star Gareth Bale. Director of football Zinedine Zidane claimed teams are unlikely to be put off by the Welshman's hefty price tag after his award-winning campaign in England.