The Spain international has urged the Santiago Bernabeu side to accept the situation as it is and has voiced his dismay with the smear campaign against Lionel Messi.
Madrid has won only one domestic title in the past five seasons to the Blaugrana's four, while the club has been unable to match its arch-rival's success in the Champions League in the 21st century, leaving Pique unimpressed with the way Madrid has behaved in public.
"It appears to be very difficult for Real Madrid that Barcelona are winning a lot of silverware," Pique was quoted as saying by Sport. "They have to accept the situation as it is. Sometimes you win and sometimes another team wins.
"Football is going in cycles and it's Barcelona's cycle now."
The center back then responded to the ongoing attacks aimed at Barcelona in general and Lionel Messi.
"People are attacking us from all angles," he continued. "Messi's case? There comes a point where you have to say 'enough'. There has to be justice at some point as people continue to accuse him of things he did not do."
Barcelona is currently preparing for the restart of La Liga at home against Elche on Sunday.