The Roja boss has shrugged off suggestions the striker's inclusion could be disruptive following a dispute with Brazil, and is confident he will adapt to the team.
The in-form Atletico Madrid star has been handed his first call-up for Spain's clashes with Guinea and South Africa after confirming his desire to play for Del Bosque's side over his native Brazil.
Although the dispute over his international selection has caused a headache for both the Selecao and Spain in recent weeks, del Bosque maintains he has no qualms over calling up the 25-year-old following his exceptional early-season form.
"He's playing very well and he ticks all the boxes," del Bosque told reporters. "I don't understand how someone with Diego's quality can be a negative for us. He'll be a great addition. Our players are able to adapt and there is no player that cannot be attached to our game."
The 62-year-old coach called for caution as Spain begins its buildup to the World Cup next summer, stressing that the reigning world and European champions must not be considered automatic favorites.
"Currently we believe that these players fully meet our needs," said Del Bosque. "But let's be cautious. Did you you see me saying we will win the World Cup?"