The Mexican winger was brought on as a sub in the second half as the Chés dominated the German side.
Pablo Piatti and Jonas opened up scoring for Los Chés in the first half and the visitors went into the break with a 2-0 lead.
Carles Gil and Feghouli scored in the second half, now with Guardado on the pitch, to shape the final scoreline.
Argentine signing Fernando Gago was present at the stadium, with the naranjeros' new defensive midfielder still awaiting his debut after his sale from Real Madrid landed him back in Spain following a loan spell at Roma.
Valencia will open its 2012-13 La Liga campaign against Real Madrid on August 19 at the Santiago Bernabeu.
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