The Dutch coach took over in October but a run of eight defeats in nine games has forced the club's board to relieve him of his duties.
Bundesliga club Nurnberg has sacked head coach Gertjan Verbeek after just six months in charge.
The Dutchman, along with assistant Raymond Libregts, has been removed from his position following a run of eight defeats in nine fixtures, which has left Nuremberg five points adrift of guaranteed safety.
Under-23 coach Roger Prinzen will take charge of the squad for the remaining three matches, assisted by Marek Mintal.
Verbeek arrived at Nurnberg in October, taking on his first managerial role outside his native Netherlands, where he had spells in charge of Heracles, Heerenveen, Feyenoord and AZ.
However, he has found life difficult in the German top flight and has picked up just five wins in 22 matches.
"After the recent run of defeats, we have intensively discussed the current, precarious situation several times to see which measures were necessary in order to be victorious in our three remaining games," chairman Martin Bader said in a statement.
"We are confident that this decision will help us find that extra something."
Turning his attention to interim boss Prinzen, Bader added: "Roger knows the team well and has already proven that he can help the team quickly in a serious situation.
"He is a positive trainer who approaches the job very realistically, but also with the necessary optimism."
Nurnberg visits Mainz on Saturday, before hosting Hannover and closing the season at Schalke.