The left back suffered a hamstring problem during Wednesday's 2-0 loss to Bayern Munich in the Champions League, but Mikel Arteta is available again after suspension.
The 24-year-old has been a regular in Wenger's first team this season, making 32 appearances in all competitions, but will be unavailable as Arsenal looks to bounce back from the European disappointment.
"We are playing in three different competitions in one week," Wenger told reporters. "It's extremely difficult to adjust every time and it's physically very demanding.
"We have fought hard so far in the Premier League and of course now we want to come back and win our home game. There will certainly be changes, that's for sure. I will decide after training [on Friday]. Kieran Gibbs is out of course and no one else is back apart from Mikel Arteta, who is back from suspension."