The Baggies have denied reports the Frenchman has retired from football, but the 34-year-old will play no part in Saturday's match against Roberto Martinez's men.
Earlier on Thursday reports circulated that Anelka had walked out of training after a conversation with sporting director Richard Garlick, and signaled his intention to retire from football. Conflicting reports suggest the 34-year-old forward has been given time off to deal with the death of his agent, and that his future remains uncertain.
Anelka joined West Brom on a free transfer in the summer, having enjoyed short spells with Shanghai Shenhua and Juventus last season. As recently as July the 34-year-old expressed his delight at reuniting with former Chelsea assistant Steve Clarke at the Hawthorns, and suggested he wanted to retire at the club.