The Ligue 1 side has condemned the group of locals who threw missiles at a bar full of Spurs supporters ahead of Thursday evening's Europa League clash between the sides.
A number of Spurs fans were targeted as they drank in a bar in Lyon's Old Town ahead of Thursday evening's Europa League last-32 meeting between the sides.
Local hooligans smashed windows in the Smoking Dog pub and threw bar stools at those trapped inside, incidents which resulted in several people requiring treatment.
The Ligue 1 outfit has now moved to apologize to travelling fans while distancing itself from the perpetrators.
"Olympique Lyonnais regrets last night's incident in Saint-Jean between supporters of Tottenham and 'pseudo' Lyon fans who do not represent the Club," a statement on the club's official website read.
"Olympique Lyonnais apologizes to Tottenham and its supporters for these unacceptable acts that degrade the image of the city of Lyon. Olympique Lyonnais calls for French justice to severely punish these wrongdoings.
"Olympique Lyonnais welcomes supporters of Tottenham tonight at the Stade Gerland and calls on all supporters, French or English, to support their team with respect and fair play."