The former Fulham man scored agaisnt Norwich City in Spurs' last game, and that goalscoring threat has seen his come into the side in place of Jake Livermore, who drops out all together.
Tottenham's other signing from Fulham, American Clint Dempsey, will start the match on the bench.
Tottenham: Friedel, Walker, Gallas, Vertongen, Naughton; Sandro, Dembele, Sugurdsson, Lennon, Bale; Defoe.
Subsitutes: Lloris, Caulker, Dawson, Huddlestone, Townsend, Adebayor, Dempsey.
Reading: McCarthy; Gunter, Gorkss, Pearce, Harte; McCleary, Karacan, Leigertwood, McAnuff; Guthrie; Pogrebnyak.
Subsitutes: S Taylor, Shorey, Mariappa, Cummings, Robson-Kanu, Le Fondre, Hunt.
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