The American star touched home a Gareth Bale pass to act as the catalyst for a come-from-behind effort in the second half of Tottenham's crucial victory.
With Tottenham trailing Manchester City 1-0 in a game with massive European implications for the London club, Dempsey slid to touch home a Gareth Bale cross in the 75th minute, sparking a three-goal surge in seven minutes that lifted his side to a 3-1 victory over City at White Hart Lane.
Bale, making his return from injury, set Dempsey up by the left post, deftly placing a cross off the outside of his left foot. The American star went to ground to redirect it past Joe Hart with his outstretched left foot and bring Spurs level after Samir Nasri's fifth-minute opener.
Tottenham was not done, though. Goals from Jermaine Defoe and Bale in rapid succession capped off the result and helped Spurs keep pace with third-place Arsenal, as they trail the Gunners by two points and have a game in hand as the race for a Champions League berth intensifies.
For Dempsey, the goal was his 11th in all competitions this season and his third in his last two matches following his Europa League brace against FC Basel.