Sergio Aguero, Edin Dzeko, Yaya Toure. Stevan Jovetic and Vincent Kompany were all on target as Spurs, who saw Danny Rose sent off, were swept aside at White Hart Lane
Sergio Aguero continued his rich vein of form to fire City into a first-half lead before he succumbed to another hamstring injury.
Manuel Pellegrini’s side coped admirably without its Argentine superstar, however, with Yaya Toure doubling the lead from the penalty spot shortly after the break following Danny Rose’s foul on Edin Dzeko, which earned the Spurs left back a straight red card.
Dzeko stabbed home the third and Stevan Jovetic curled home his first Premier League goal after Etienne Capoue had bundled in a consolation, while captain Vincent Kompany rounded off another emphatic victory.
Tim Sherwood made one change from the victory at Swansea, with Gylfi Sigurdsson replacing Nacer Chadli.
Manuel Pellegrini made five alterations to his City side after the FA Cup scare against Watford, including recalls for captain Kompany and David Silva.
Aguero had scored six times in his previous four games following his injury layoff and almost added another early on when he rattled the post from a tight angle.
City's early dominance was rewarded four minutes later, though, when Silva slipped in a perfect ball for Aguero and he delicately stroked his shot past the onrushing Hugo Lloris from 10 yards.
Emmanuel Adebayor's curling effort was deflected wide soon afterwards, but Spurs were indebted to Lloris after 20 minutes when he made a stunning one-handed save to keep out Aguero's pinpoint header.
Michael Dawson thought he had brought Tottenham level after 36 minutes when he prodded in a fantastic Christian Eriksen free-kick, but he was ruled marginally offside.
There was controversy a few moments after halftime when Dzeko was played in on goal, only to be thwarted by Rose with a tackle from behind. Referee Andre Marriner awarded a penalty and sent the defender off.
Toure dispatched the penalty into the corner for his 15th goal of the season.
City ensured an 18th win from its last 20 games after 53 minutes when Silva's rasping drive was brilliantly tipped onto the post by Lloris, only for the ball to eventually fall to Dzeko, who slotted home with ease.
Tottenham did pull one back six minutes later when City failed to deal with a corner and Capoue latched onto the loose ball to hammer home from six yards.
But a perfect night was rounded off late on when Jovetic found space in the area to thump beyond Lloris via a deflection, and Kompany's late effort rounded off a five-star performance.