Los Angeles mounted a comeback after going down early, but it wasn't enough as Tijuana made it through to the CCL semifinals.
The Major League Soccer side won its home leg 1-0, but Tijuana wasted little time getting the series back on level terms. A hashed Galaxy clearance left the ball to Dario Benedetto, who was taken down from behind in what probably would have been a penalty had Jaime Ayovi not followed up with a goal.
Ayovi nearly made it 2-0 not long after, collecting a loose ball in the box and pinging his shot off the crossbar.
He made up for it in the 10th minute however, collecting a long ball over the top, outpacing the Galaxy defense, taking the ball past Jaime Penedo's onrushing challenge, and slotting home to give the Xolos the aggregate lead.
Tijuana made it 3-1 in the 26th minute. Galaxy defender Leonardo failed to deal with a simple long ball, and Benedetto had an easy task to take it off him and beat Penedo.
Robbie Keane pulled one back almost immediately after halftime. Landon Donovan's free kick found Omar Gonzalez at the far post, anf the defender headed down across goal for Keane to tap in.
Substitute Richard Ruiz put Tijuana up in the 82nd minute, volleying a flicked-on header from a wide position past Penedo and into the goal.
The visitors struck back shortly after, with Landon Donovan feeding Robbie Keane on an 85th-minute counter. The Irishman did well to get his shot off under pressure from two Tijuana defenders and keeper Cirilo Saucedo to bring the Galaxy within a goal of progression before time ran out.
The Galaxy's exit leaves just a pair of MLS entrants left in the competition. San Jose travels to Toluca on Wednesday night after a 1-1 draw in Northern California, and Sporting Kansas City visits Cruz Azul holding a slender 1-0 advantage.