Brendan Rodgers' side will be looking to continue its impressive recent form when it visits a ground where it has not tasted victory in more than a decade.
Yoshida, Hooiveld, Fonte, Shaw
Puncheon, Ramirez, Lallana
Johnson, Carragher, Agger, Enrique
Downing, Suarez, Coutinho
Mauricio Pochettino has a fully fit squad to choose from, with Steven Davis (illness) and Danny Fox (thigh) having returned to following time spent on the sidelines.
The Southampton manager faces a selection headache over his back four, following Maya Yoshida's solid performance in an unfamiliar right back position in the 0-0 draw at Norwich. The Japanese defender may retain his place in the team ahead of usual fullback Nathaniel Clyne.
The pace of Jason Puncheon may be preferred to the guile of Jay Rodriguez, who started on the wing at Carrow Road.
Pepe Reina faces a late fitness test after missing much of the last week's training due to a calf injury, meaning Brad Jones could keep his place in the Liverpool goal.
Brendan Rodgers admitted that Joe Allen will require surgery on a long-standing shoulder injury, but the Welshman is still expected to be involved on Saturday.
The Reds manager has no further injury concerns, with Martin Skrtel now back in contention and challenging Jamie Carragher for a place in central defense.
|DID YOU KNOW?|
Southampton has won three of its last four home games against Liverpool, with each victory coming by a 2-0 margin.
The Reds are aiming to win four consecutive Premier League games for the first time since February 2011.
Mauricio Pochettino has only won one of his seven games in charge since replacing Nigel Adkins - 3-1 at home to Manchester City.
Only Jamie Carragher and Steven Gerrard remain from the last time these two sides went head-to-head at St. Mary's, back in January 2005.
Southampton striker Rickie Lambert (pictured right) was a member of the Liverpool academy as a boy, and is a self-confessed Red.
Meanwhile, Adam Lallana admits to supporting Everton as a youngster, so he will be especially keen to get one over on the Saturday's opponents.
Out of all the major European leagues, only Lionel Messi, Cristiano Ronaldo and Zlatan Ibrahimovic, have scored more league goals than Luis Suarez so far this season.
- Rickie Lambert is the highest-scoring Englishman in the Premier League, with 11 goals.
With 19, Liverpool has had more shots per game than any other major European side, but average less than six on target.