Eusebio Di Francesco's men have endured a tough start to the season, having been promoted in May, while the Nerazzurri are riding on a wave of optimism
New coach Walter Mazzarri has turned things around at San Siro following a disappointing 2012-13 campaign, with Inter having picked up two wins and a draw from its opening three matches.
Serie B champion Sassuolo, meanwhile, is looking to claim a first point of the season when the two sides go head-to-head at the Tricolore.
Eusebio Di Francesco's side has lost all three of its games so far - including two against sides with whom it was promoted at the end of last season.
But, while Inter goes into the game as a strong favorite, the club's president Massimo Moratti has urged caution from his side.
"Inter are the team who have to play against Sassuolo, a side new to Serie A brimming with enthusiasm," he said. "They’re an opponent we should fear because results are never decided in advance and often you find that the emotional factor makes a big difference in games.
"I know we have a coach capable of instilling the right level of focus in the players. That's something Mazzarri is very good at and I'd like to see the same level of quality, strength and determination that we saw against Juventus."
Inter comes into the game having earned a hard-fought point against defending champion Juventus last time out, whereas Sassuolo suffered a defeat to Verona.
Rodrigo Palacio leads the scoring charts for Mazzarri's side with two goals, while new signing Mauro Icardi struck the opening goal of the game against Juventus.
But it is in defense where the new coach appears to have had the biggest influence, with his back three of Jonathan, Juan and Andrea Ranocchia having only conceded one goal so far.
Di Francesco will be looking to experienced players such Reto Ziegler, Marcello Gazzola and Antonio Floro Flores to take the lead following his side's poor start.
And, while the early struggler will be without Emanuele Terranova, Luca Marrone and Alberto Aladje could be fit to return.
For Inter, the only concern is Ranocchia who picked up a knock against Juventus, although he should be fit enough to play.