Marco Parolo's last-minute strike secured a 3-2 win over the Rossoneri last time out and the reigning champion has not won at Ennio Tardini since Jan. 2010.
Antonio Conte's men recorded convincing home wins over Genoa and Catania to undo some of the damage inflicted upon the club by the 4-2 loss at Fiorentina, when the team surrendered a two-goal halftime lead.
That result saw the champion lose ground on Serie A leader Roma, but the team's overall form, which has seen it drop just five points from the 30 available, still has it in a strong position heading into Saturday's match.
The team's response to the setback has been impressive, with six goals scored in the previous two games without reply - while only Roma and Inter can better Juve's haul of 22 strikes this term.
Parma's home record has bailed the club out of trouble after Roberto Donadoni's charges kicked off the campaign with a four-match winless run.
A three-game winning streak at the Stadio Ennio Tardini - including a dramatic 3-2 triumph over AC Milan - has lifted the team to the relative safety of mid-table, but it has not beaten this weekend's visitor in the last four meetings.
Parma has fared relatively well against Juve on home soil in the team's two most recent title-winning seasons, holding it to a goalless stalemate in the 2011-12 campaign and a 1-1 draw last term.
Juve's last win in Parma came in January 2010, when a Paolo Castellini own goal sealed a 2-1 victory for the visiting side.
The home team will look to Marco Parolo for inspiration, with the 28-year-old midfielder having scored five of the club's 16 league goals, including a double in the win over the Rossoneri.
Neither side has any fresh injury concerns, with Fabio Quagliarella and Mirko Vucinic unlikely to return from their thigh injuries for Juventus. Carlos Tevez and Arturo Vidal - with seven and eight goals apiece in all competitions this season - will look to carry the Bianconeri threat.