Jack Wilshere is available for selection after serving a two-game suspension but Aaron Ramsey will miss the trip to St James' Park with a thigh injury.
Alan Pardew's men have won seven of their last nine Premier League fixtures, with their latest success a 5-1 hammering against Stoke City on Boxing Day.
That run - which includes victories over Chelsea, Tottenham and Manchester United - has seen Newcastle move to within three points of the Champions League places.
However, Arsenal is undefeated in its last six league trips to St James' Park, although the London club has triumphed in just two of those encounters.
Pardew is relishing the visit of Arsenal, though, and feels the clash will give him a better idea of the capabilities of his side.
"We've set ourselves up for what will be an intriguing encounter and we'll probably know a little bit more about this team after Arsenal," Pardew said. "We've been on an incredible run really. I'm not sure if any team has beaten that run over the last nine or 10 games this season, not even Arsenal."
Midfielder Cheikh Tiote returns from suspension for Newcastle after missing the win over Stoke, leaving Pardew with almost a full squad to choose from.
Arsenal will be boosted by the return of Jack Wilshere following his two-game ban for making an offensive gesture towards Manchester City fans earlier this month, but Aaron Ramsey misses out after picking up a thigh injury in Thursday's 3-1 win over West Ham.
Laurent Koscielny is a doubt due to a knee problem, while Alex Oxlade-Chamberlain is also likely to be unavailable with a similar injury, although the winger is thought to be nearing his return.
The visitors' Boxing Day triumph against West Ham was their first in four league matches and moved them back to the summit of the division.
Wenger felt the victory at Upton Park underlined Arsenal's title credentials, but midfielder Tomas Rosicky is expecting another stern test of their character against Newcastle.
"Obviously it will be a tough game but Newcastle will always give you a good match," Rosicky told Arsenal's official website. "It will be very interesting, I love these kind of games so I'm very much looking forward to playing them. I think it will be an exciting match."