New England took full advantage of a shorthanded Galaxy squad and earned three valuable points.
Saer Sene opened the scoring in the 34th minute. A well-worked give-and-go with Diego Fagundez set Sene free in the box, and he calmly slotted it home.
Lee Nguyen doubled the lead in the 71st with a deflected shot from the top of the box.
Fagundez would round out a nice individual game with a goal in the 87th minute, with Chad Barrett adding a fourth in stoppage time for good measure.
Kelyn Rowe added a fifth in the last minute of the game, giving the home fans a win to remember.
LA was without Robbie Keane and Omar Gonzalez, who were on international duty.