The Scot takes charge of the Red Devils' first European game of the post-Ferguson era and will be looking to make full use of home advantage when Sami Hyypia's men come to town.
The Red Devils head into Tuesday's encounter against the Germans ready to compete at the business end of the Champions League for an 18th successive season, with their sights set on a fourth title. Although it is business as usual for the Premier League champion, the match represents new territory for the club's new manager.
The Scot faces a dilemma over the fitness of Wayne Rooney after the England striker played the full 90 minutes of United's 2-0 win against Crystal Palace on Saturday wearing a special headband to protect a head wound that ruled him out of international duty.
Meanwhile, in the opposing dugout on Tuesday will be a fellow rookie in the competition in the shape of Sami Hyypia, a former player with United's Premier League rival, Liverpool, and a winner of this trophy as a player with the Anfield club back in 2005.
Leverkusen makes the journey to Old Trafford having never won in the country after two draws and six losses on English soil.
While United only added Marouane Fellaini to the first-team squad as the transfer window slammed shut, Leverkusen made no fewer than 10 additions to the group available to Hyypia, while 13 players departed during a busy close season.
The new-look squad appears to have gelled well as it sits in third place in the Bundesliga after five matches, with Hyypia once again likely to look to in-form duo Sidney Sam and Stefan Kiessling to lead the charge, with both having scored four times already this campaign including in Saturday's 3-1 win over Wolfsburg.