With the title slipping from the current Premier League champion's grasp, the away side will look to capitalize and go within a point of the team above it with a win.
Roberto Mancini is likely to make several changes from the rotated side that beat Leeds 4-0 in the FA Cup as regulars Joe Hart, Gael Clichy and Edin Dzeko are all likely to replace Costil Pantilimon, Aleksandar Kolarov and Carlos Tevez.
The home side could also receive a much-needed boost with captain Vincent Kompany currently striving to return from a calf injury in time for the game. If he passes a late fitness test he should return in place of Kolo Toure.
Gareth Barry (knock), however, remains doubtful while Micah Richards (knee) will definitely not feature.
Rafa Benitez is also set to make a variety of changes from the side that drew against Sparta Prague in the Europa League on Thursday, as Frank Lampard, Branislav Ivanovic and Ashley Cole, all rested in that game, should return at the expense of John Obi Mikel, John Terry and Ryan Bertrand.
Eden Hazard, following his late tie-winning contribution in Thursday's game, should also come back into the starting line-up, with Oscar likely to be the man that drops to the bench.
Demba Ba should also, once again, come in for Fernando Torres to lead the line after missing out on the Europa League tie, having already featured in the competition for Newcastle.
|DID YOU KNOW?|
- Manchester City has managed to win just one of its past four Premier League encounters with Chelsea, losing two and drawing the other.
- Chelsea won 10 of its first 12 away league games against the current champion, but City has won the last three clashes at the Etihad Stadium.
- Manchester City striker Edin Dzeko has scored six goals in his last seven Premier League appearances.
- The sides are well-matched, with City boasting this season's second-best home record, while the visitors have the second-best away form in the league, with Manchester United leading both tables.
- Meanwhile, Chelsea's Frank Lampard (pictured) will be looking to score in his fifth consecutive league game for only the third time in his career (having previously done so in 2005 and 2010).
- The Blues have been awarded eight penalties this season, the most in the Premier League, though their opposition today has, aside from rivals Manchester United, enjoyed the most spot-kicks in the league since the start of last season (14).
- Fernando Torres will be looking to recover from a torrid recent spell of form if he features here, having scored just one in his last 13 games; against Sparta Prague on Thursday, he had more shots than anyone else on the pitch and not only did he fail to score, but only one of those was on target.
- The Blues are 13th in the table when it comes to losing the lead in matches this season, having dropped 14 points from winning positions.