Brendan Rodgers' side takes on Nigel Adkins' Saints, who have been involved with more goals than any other team in the Premier League after scoring 21 and conceding 31.
Wisdom, Skrtel, Agger
Johnson, Allen, Gerrard, Enrique
Sterling, Suarez, Suso
Clyne, Fonte, Yoshida, Shaw
Puncheon, Ramirez, Lallana
Although his injury list has not been painstakingly-long, Brendan Rodgers will have been annoyed that many of the problems were not expected to be cleared before 2013, but there has been good news for one player.
Lucas Leiva (thigh) has managed just two Premier League appearances all season and was not initially expected back until mid-to-late December, but the Brazilian looks set to be available for selection on Saturday, though he may not start.
Martin Kelly (knee) continues to miss out and will not be back before February, while Fabio Borini (foot) appears to have been ruled out of action for the rest of 2012 too, but should return in January.
Nigel Adkins has just about a full squad to pick from for the trip to Anfield on Saturday, with just two players expected to miss out, neither of whom are certain starters.
Richard Chaplow (thigh) is still expected to be missing for another week or so, while Frazer Richardson (hip) will also have to continue his spell on the sidelines this weekend.
The potential return of Daniel Fox (knee) represents some good news for Adkins, with the defender set to undergo a fitness test on Friday and expected to at least travel with the squad on Saturday.
|DID YOU KNOW?|
Southampton came out victorious in three of its previous four league meetings with Liverpool.
Nigel Adkins’ side has been involved in more goals than any side (52). Manchester United comes closest to with 51.
Adkins' team has also dropped more points from winning positions that any other club, 15.
Liverpool is the only team yet to score in the final 15 minutes of a Premier League match this season.
Steven Gerrard and Luis Suarez (both pictured right) are the only players to have netted more than once for the Reds.
Five Saints players have managed more than one goal so far, and Rickie Lambert leads the pack with six strikes.
Since his 7 million pound move from Burnley in the summer, Southampton's Jay Rodriguez has just the one league goal in 12 appearances.
Just 14 percent of Liverpool’s crosses from open play have been met by a teammate, the worst mark in the Premier League.
Of their 16 league matches at Anfield in 2012, the Reds have won just four.