The Galaxy welcome Real Salt Lake with the hosts hoping to get revenge for their playoff exit last season.
Salt Lake knocked LA out with a 2-1 aggregate win in the Western Conference semifinal.
Neither team made massive changes during the offseason, though this will be Jeff Cassar's first game in charge of the Utah outfit. He takes over from Jason Kreis, who left to lead 2015 expansion club New York City FC.
The Galaxy this week re-signed leading scorer Robbie Keane to a deal that could keep him in Southern California for another three years. They'll be without Jose Villarreal this season as he is on loan at Cruz Azul.
READ MORE: Goal's full 2014 MLS preview
Cassar will be without forwards Robbie Findley (knee) and Devon Sandoval (foot) and center back Chris Schuler (foot), who scored the winning goal in the 2013 playoff tie. Bruce Arena likely won't have the services of Robbie Rogers (ankle).
The game kicks off at 10:30 p.m. ET and is available on MLS Live.