After recording their first victory of the season against rival Newcastle, Gus Poyet's charges head to the KC Stadium, where the Tigers have been strong in 2013-14.
On-loan Liverpool forward Fabio Borini came off the bench to score the goal that defeated the Magpies 2-1 at the Stadium of Light, enhancing his claims for a starting berth as the Black Cats bagged their first victory of the season.
Sunderland manager Gus Poyet told the club's official website: "I know a few managers prefer to have 11 in there and not too many pushing for a place but I like to have those problems. It's then up to me to make decisions."
Despite triumphing against Newcastle, however, Sunderland is 19th in the Premier League and four points from safety.
Hull, which many observers expected to struggle on its return to the top flight, is much more comfortably-placed in 10th, despite losing its last two league matches. Bruce's men are also unbeaten at home, having picked up eight points from four matches at the KC Stadium thus far.
However, if Bruce - who managed Sunderland between June 2009 and November 2011 - is to oversee a fourth league win of the campaign, his side must overcome an awful recent record against the Wearside club.
Sunderland has won each of the previous six meetings between the teams, conceding only two goals in the process - both in 4-1 victories.
Hull is hampered by a lengthy injury list, added to when Alex Bruce (groin) and Aaron Mclean (calf) picked up problems during Wednesday's Capital One Cup tie with Tottenham, which was eventually won on penalties by Andre Villas-Boas' men.
Goalkeeper Allan McGregor (thigh) and center back James Chester (hamstring) remain on the sidelines, while Sone Aluko and Robbie Brady are rated as doubtful. The former is battling a calf problem, while the latter has yet to regain full fitness after hernia surgery.
Sunderland's Jozy Altidore, whose only goal so far this season came against MK Dons in the Capital One Cup, scored just once in 28 Premier League appearances for Hull in the 2009-10 season.