The two sides enjoyed success in the Champions League in midweek and will be hoping to build upon those good results when they meet in domestic action.
Bayern thrashed Manchester City 3-1 at the Etihad on Wednesday to continue the positive start to life under new coach Pep Guardiola. Leverkusen was also victorious in the Champions League, though it was made to sweat by Real Sociedad before securing a 2-1 win over the Spanish side courtesy of a 92nd-minute winner from Jens Hegeler.
Domestically, this weekend's meeting at the BayArena represents third against second, with Leverkusen sitting just a point behind its visitor after a good start of its own. Both sides are in the midst of fine runs in home league games, with each of their last defeats on home soil coming against the other.
Sami Hyypia's men have won all of their home matches since a 2-1 defeat to the Bavarians back in March. Philipp Wollscheid's own goal in the 87th minute did the damage on that day, after Simon Rolfes had cancelled out Mario Gomez's opener.
Bayern is in strong form ahead of the gam, as Guardiola has seen his side win each of its last six games, scoring 17 goals and conceding just twice. The Catalan coach is without long-term absentees Thiago Alcantara and Holger Badstuber (both knee), but Javi Martinez could be back in the squad after groin surgery, and Mario Gotze's comeback from an ankle knock is likely to continue after a substitute appearance against Manchester City.
Meanwhile, Leverkusen's only injury doubt is Gonzalo Castro (hamstring).