The home side has won just once at Villa Park, defeating Manchester City, but faces a Toffees team fresh from a home win over Hull and sitting seventh in the Premier League.
The Toffees have made an impressive start to life under new boss Roberto Martinez, who took over from David Moyes in the summer, suffering just one defeat in their opening eight top-flight fixtures.
Martinez's men bounced back from the disappointment of that 3-1 loss against Manchester City in ideal fashion, picking up a 2-1 victory over Hull to leave them seventh - just four points adrift of top club Arsenal.
With eight teams not playing until Sunday, Everton has the chance to put itself among the front-runners against a Villa side whose home form has been difficult to predict this season.
A 3-2 victory over Manchester City has been the club's undoubted highlight of the campaign so far, but a 2-1 defeat to Newcastle on September 15 will give Everton the belief that it is more than capable of picking up three points.
In fact, that win over Manuel Pellegrini's men is Villa's only home triumph of the season so far - with their other successes coming away at Arsenal and Norwich - but Paul Lambert's side is currently sitting on twice as many points (10) as it was at this stage last season.
As the most played fixture in English league football, there is no shortage of history to draw on in trying to pick a winner for this clash, with Villa just edging the stats with 72 wins to 71 from their 196 league meetings.
Martinez expects another tough encounter this time around.
"We won't underestimate their quality, that's for sure," the Spaniard said. "Anyone that can beat Arsenal or Manchester City deserves huge credit.
"When they have everyone fit and available, they are as good as anyone on their day."
Martinez will not be happy to learn that Christian Benteke is fit and ready for action. The Belgian striker, who has five Premier League goals to his name this term, has not started since picking up a groin injury at Norwich in September, but made his comeback as a substitute in last Sunday's 2-0 defeat to Tottenham.
Ciaran Clark is likely to return from a bug that kept him out last weekend, while Gary Gardner and Marc Albrighton are doubts with back and throat problems respectively. Charles N'Zogbia (Achilles) and Jores Okore (knee) are long-term absentees.
For the visiting side, John Heitinga could be missing after sitting out the win against Hull with a muscle problem, while Darron Gibson (knee) and Antolin Alcaraz (hamstring) remain sidelined.