Both sides were defeated on matchday one but will be looking to get their Champions League campaigns under way when they clash in Brussels.
Both Anderlecht and Olympiakos will be hoping to get off the mark when they meet in the Champions League on Wednesday.
The two sides tasted defeat in their opening Group C matches, the Belgians losing 2-0 to Benfica while the Greeks were thumped 4-1 at home by Paris Saint-Germain.
Wednesday represents the first meeting between the two sides since 1974, when Anderlecht squeezed through 5-4 on aggregate in the second round of the European Cup after winning the first leg 5-1 in Belgium.
The reigning Belgian Pro League champion is unbeaten in its last seven games against Greek opposition, and the club's record at home to sides from the Mediterranean country reads four wins and two defeats from six matches.
Olympiakos’ last game against a club from Belgium came in the group stage of the Champions League four years ago, when the team defeated Standard Liege 2-1 in Greece before going down 2-0 in the return fixture.
Anderlecht finished bottom of its group last season, while Olympiakos finished third in group play and entered the Europa League, where the club was knocked out immediately by Levante of La Liga.
John van den Brom's men currently lie fourth in the Belgian top flight, nine points adrift of Liege after winning six and losing three of their opening nine fixtures. They will go into Wednesday’s game on the back of Sunday’s 2-0 home success over Lierse, Guillaume Gillet and Dennis Praet the goalscorers.
Ronald Vargas is a long-term injury absentee for Van Den Brom after undergoing knee surgery in July.
Olympiakos has enjoyed a fine start to its domestic season though, holding a three-point lead over PAOK at the top of the Greek Super League with five wins and a draw from the opening six matches, including Saturday’s 2-0 success at Panionios.
David Fuster and Paulo Machado are unlikely to feature with hamstring and knee problems, while Michel’s side will be looking to avoid falling to its 100th defeat in European competition at the Constant Vanden Stock Stadium.