Graham Arnold's men have every chance of triumphing when they clash with the new-look City at a neutral venue this week, while the Wanderers should be wary of a potential upsetMelbourne City are favourites to beat Sydney FC in the first competitive match under their new guise, while Adelaide City are at long odds to upset Western Sydney as the FFA Cup round of 32 continues.
The club formerly known as Melbourne Heart host the Sky Blues in Ballarat, where John van 't Schip's men are $2 favourites at bet365.
Graham Arnold's visitors are paying a generous $3.25 to reach the last 16, with the draw worth $3.40.
Elsewhere on Tuesday, former National Soccer League side Adelaide City are a lengthy $5 to get the better of last season's beaten grand finalists.
Tony Popovic's men will surely have one eye on their forthcoming AFC Champions League quarter-final with Chinese Super League powerhouse Guangzhou Evergrande.
Nevertheless, punters are backing the Wanderers to get the job done and they are offering a return of just $1.50 to win in South Australia this week.
In the other games, Blacktown City ($1.90) are expected to get the better of Bentleigh Greens ($3.10), while Sydney United 58 ($2) against FNQ FC Heat ($2.87) is tougher to call.