Brendan Rodgers' side are paying $1.66 at bet365 to win at Anfield, where at Chelsea are worth $5.00 and the draw is on offer at $4.00.
Blues boss Jose Mourinho has flagged the possibility of fielding a weakened team as he prioritises next week's UEFA Champions League semi-final second leg at home to Atletico Madrid.
That would appear to leave the way open for the Reds to move eight points clear of Chelsea at the top of the table, and gain revenge for the 2-1 loss they suffered at Stamford Bridge in December.
Liverpool's last league win over the west London side was a 4-1 home triumph in May 2012, and you can get $23.00 on a repeat of that scoreline, not a bad bet considering the rampant home form of Rodgers' team at times this season.
As always, Luis Suarez dominates first goal-scorer betting at $4.00 to strike first in the game, or $1.72 to hit the back of the net at any time throughout the contest.
Better value would be lightning-fast forward Raheem Sterling, who is priced at $10.00 to break the deadlock at Anfield.