The Red Devils are being backed in to make light work of their visitors from East Anglia when a club stalwart experiences his first taste of the hot-seat
Set to be led by interim coach Ryan Giggs, United are $1.36 favourites at bet365 to win at Old Trafford, where the relegation-threatened visitors are priced at $8.50 and the draw is worth $4.75.
The Canneries, having made their own managerial switch by axing Chris Hughton in favour of academy boss Neil Adams, pushed leaders Liverpool hard only to lose 3-2 at home last time out.
United are seeking to bounce back from defeat at the hands of Everton, which signalled the end for former Toffees boss Moyes.
United won 1-0 at Carrow Road in the teams' first meeting this season, with Daniel Welbeck, who had fallen from favour late in Moyes' reign, supplying the goal.
You can get $8.50 on a repeat of that scoreline in United's favour, and $5.00 on Welbeck opening the scoring, or $2.05 on the England forward finding the back of the net at any point in the game.
Everton ($2.37) can return to fourth place if they beat Southampton ($2.90) away from home, with the draw at St Mary's Stadium on offer at $3.40.
Tottenham meanwhile, looking to seal sixth spot and a UEFA Europa League berth for next season, are $2.30 favourites to win at Stoke City ($3.10). You can get $3.25 on a draw at the Britannia Stadium.