The north London side are unfancied to come away from their trip to Merseyside with all three points, while the title-chasing Reds are expected to continue their winning run
Arsene Wenger's side go into the game at Goodison Park fourth on the table, just four points ahead of the Toffees.
The Gunners are paying $3.00 at bet365 to win, with Everton the $2.50 favourites and the draw on offer at $3.40.
The last time they met was in the FA Cup last month, a game that produced a comfortable 4-1 victory for Arsenal.
You can get $51.00 on them repeating that feat on the road.
A better guide is the team's 1-1 draw at the Emirates in December, as well as their 0-0 stalemate at Goodison Park last April.
A goalless draw this time around if paying $11.00, while another 1-1 is on offer at $6.50.
Everton's on-loan Belgian striker Romelu Lukaku is the shortest player in first goal-scorer betting at $5.50, with Arsenal's French frontman Olivier Giroud second at $6.50 to break the deadlock in the game.
Elsewhere on Sunday, Brendan Rodgers' Liverpool are paying just $1.40 to win away to West Ham ($9.00), with the draw at Upton Park worth $5.00.
The Reds have been in confident mood of late, and you can get $9.00 on a 2-0 win in this one, or $10.00 on the visitors to run out 3-0 winners.