The trio of heavyweight clubs are being backed in to triumph in style this weekend, meaning the smart money has to be placed carefully, or punters should look elsewhere
City ($1.33) are expected to account for Southampton ($10.00) at Etihad Stadium, while Stoke City ($13.00) are being given little chance of winning at Chelsea ($1.28).
United ($1.95) meanwhile go to out-of-form Newcastle ($4.20) fresh from their 1-1 draw with Bayern Munich in the UEFA Champions League, with the draw at St James' Park tempting at $3.70.
The previous meeting between these two saw Newcastle register a 1-0 win at Old Trafford, and you can get $8.50 on United gaining revenge and winning by the same scoreline.
A 2-0 victory for the visitors is at $10.00, while 2-1 is priced at $9.00.
There is better value to be found elsewhere, with Hull City paying $2.75 to see off struggling Swansea ($2.80), and a Crystal Palace victory away to relegation rivals Cardiff worth $3.25, with the home side at $2.45.