The Italian giants and the Portuguese heavyweights are expected to account for their respective opponents with ease this week, but there are options for careful puntersJuventus and Porto are both short priced favourites for their UEFA Europa League quarter-final first legs away to Lyon and at home to Sevilla respectively.
Juve, reigning Serie A champions and on track to retain their title, are paying $1.70 at bet365 to win away to Ligue 1 side Lyon, who are a lengthy $5.75 to come out on top in front of their own fans.
The draw at the Stade de Gerland is worth $3.80.
Antonio Conte's side go into the game fresh from a 2-0 loss away to Napoli in the league, but had won four matches in succession prior to that, and were unbeaten since a Coppa Italia loss to Roma on January 22.
Lyon meanwhile went down at home to Saint-Etienne last time out, making it three losses in four games from all competitions, with Remi Garde's side down to fifth in the table.
Juve are close to unbackable $1.14 favourites to advance from the tie, with Lyon unfancied at $5.50.
The first goal-scorer betting market is dominated by players from the Italian side, with Chilean midfielder Arturo Vidal perhaps worth a look at $7.50. Lyon's Bafetimbi Gomis is paying $9.50 to hit the back of the net first.
Elsewhere on Thursday night, Liga Sagres heavyweights Porto are $1.85 favourites to win at home to La Liga side Sevilla ($4.50), with the draw at Estadio do Dragao paying $3.75.
Porto, Europa League winners in 2011, are $1.61 to advance, with Sevilla at $4.50.
In the other quarter-final first legs, AZ ($5.50) are at home to Benfica ($1.72), while Basel ($3.60) await the visit of Valencia ($2.15).