The Spanish giants and the German juggernaut are expected to make short work of their respective opponents in the quarter-final first leg of UEFA elite club competition
Barca are paying $1.50 at bet365 to win their all-Spanish quarter-final at Camp Nou, with the visitors from the capital worth a lengthy $7.50 and the draw priced at $4.50.
In the other game, holders and newly crowned Bundesliga champions Bayern are just $1.47 to come out on top at Old Trafford, where United are a huge $7.50 in front of their own fans. The draw is on offer at $4.75.
Both of the Liga clubs go into their clash in good form, with Atleti having won their last six matches in all competitions, while Barca have recorded five victories in succession. The last two meetings between these two sides both produced 0-0 draws, and you can get $13.00 on a repeat of that scoreline, as unlikely as it seems given both club's riches of attacking talent.
With those creative forces in mind, over 2.5 goals in the game is the $1.70 favourite, with under 2.5 paying $2.10.
United and Bayern meanwhile last went head to head in April 2010, when the Bavarians staged a comeback, losing 3-2 at Old Trafford but progressing 4-4 on aggregate courtesy of the away goals.
You can get $41.00 on a repeat of that scoreline in United's favour, but a victory for the Germans seems far more likely given their embarrassment of world-class players and imperious form to date in 2013-14.
A 1-0 Bayern win ($8.00) is perhaps being too kind to United, with a 2-0 ($7.50) or even 3-0 ($10.00) away victory tempting.