Brendan Rodgers' side will bring their brand of attacking football to the home of fierce rivals the Red Devils this weekend, and punters will be tempted to back the visitorsLiverpool are slight outsiders with bookmakers bet365 but will be many punters' favourites when they go away to Manchester United in the Premier League on Sunday.
Brendan Rodgers' side are paying $2.70 to win at Old Trafford, where the home side are at $2.50 and the draw is worth $3.40.
United won the last meeting between these teams this season 1-0 at home in the League Cup in September, while Liverpool came out on top by the same scoreline in a league meeting at Anfield earlier that month.
You can get $11.00 on another 1-0 United win, or $13.00 for the visitors to triumph by that scoreline.
But the Reds have been flying lately, netting 15 goals in their last five games and losing just one of those fixtures away to Arsenal in the FA Cup.
Perhaps with Liverpool's attacking form in mind, bet365 are offering $1.70 on there being more than 2.5 goals in the game.
Daniel Sturridge's early goal saw the Reds lead from the fourth minute to the final whistle at Anfield last year, and if you think Liverpool will be in charge throughout, go for the away team to be in front at half-time and full-time at $4.50.
Better yet, you can get $7.00 on a half-time draw and full-time Liverpool win.
Also on Sunday, fifth meets third respectively when Tottenham play host to Arsenal in the north London derby.
Both teams go into the game off the back of European disappointment. Tim Sherwood's Spurs, paying $2.90 to win at White Hart Lane, went down 3-1 at home to Benfica in the UEFA Europa League on Thursday night.
Arsenal meanwhile, $2.37 favourites to win the derby, bowed out of the UEFA Champions League at the hands of Bayern Munich on Tuesday, losing their round-of-16 tie 3-1 on aggregate following a 1-1 draw in the second leg at the Allianz Stadium.
The draw in this one is worth $3.30 and is certainly due - the points haven't been shared between these sides since February 2009.