The Latics pulled off a memorable upset victory in last season's final, Ben Watson scoring in the 91st minute to seal a 1-0 win. Although it's not at Wembley this time, another result by the same scoreline in the minnows' favour is worth a whopping $41.00 at bet365, and is surely the only way the team from the DW Stadium will progress.
Wigan lifted the trophy for the first time in their history in May only to be relegated from the Premier League soon afterwards, before losing manager Roberto Martinez to Everton.
Now in the Championship and pushing for a playoff berth at the end of the season in a bid to make an instant return to the top flight, the Latics go away to Etihad Stadium under Uwe Rosler, a fan favourite during his four-year stay at City as a player between 1994 and 1998.
They are a massive $17.00 at bet365 to inflict another giant-killing this weekend, with City paying just $1.14 and the draw worth $7.50.
Elsewhere, League One side Sheffield United are paying $2.20 to win at home to Championship strugglers Charlton ($3.40), with the draw in that one on offer at $3.20.
In a clash between two Premier League sides, Sunderland, beaten League Cup finalists at the hands of Man City last weekend, are $3.50 outsiders to win away to Hull City ($2.15), with the draw at $3.20.