Arsene Wenger's Gunners are marginal favourites to win on the road at the Stadio San Paolo, where Rafael Benitez's hosts are out of form but fighting to progress
Basel, Schalke, Arsenal, Borussia Dortmund, Napoli, Zenit Saint Petersburg, Porto, AC Milan and Ajax are all fighting for spots in the next round, while Chelsea, Atletico Madrid and Barcelona have already advanced to the last 16.
In Group E, Chelsea are the $1.20 favourites with bet365 to finish the group stage on a high and beat Steaua Bucharest at Stamford Bridge.
Steaua, winless with just three points from five matches, are the $17.00 outsiders to claim a surprise victory in London, with the draw at $7.50.
In Germany, third-placed Schalke are rated a $1.70 chance to beat second-placed Basel, who are $5.25 to win away from home, with the draw at $4.00.
Schalke are just one point behind Basel, who only need a draw to advance to the next round but were beaten 1-0 by the German outfit earlier in the group stage.
In Group F, leaders Arsenal are $2.85 to defeat third-placed Napoli in Italy, with Rafael Benitez's men at $2.50 for the home victory and the draw at $3.60.
Marseille, yet to claim a point in the group stage, are the $7.50 outsiders at home to Borussia Dortmund, who will all but advance to the last 16 with a win in France.
Dortmund are rated a $1.44 shot to beat Marseille, with the draw, which could see Jurgen Klopp's men ousted from the competition depending on the result in Napoli, at $5.00.
In Group G, Atletico Madrid, already guaranteed a spot in the next round, are the $2.20 favourites at home to Porto, who must win to have any chance of sneaking into the round of 16.
Porto are rated a $3.50 chance for the win in the Spanish capital, with the draw at the same price.
Zenit Saint Petersburg are $1.61 to beat Champions League debutants Austria Wien in Vienna and secure their place in the knockout stage.
Wien are a $6.00 shot to claim their maiden win in the group stage, with the draw at $4.20.
In Group H, Barcelona are the $1.18 favourites to account for Celtic at home, with the Scottish side at $19 to cause the upset of the night, and the draw at $8.00.
Finally, Milan are $1.66 to beat Ajax and advance to the round of 16, with the draw $3.80 and the Dutch team at $6 for the win.