The clash between the two favourites to win this season's title in Chelsea and Manchester City at Stamford Bridge.
While Arsenal might be the surprise early leaders this season after eight matches, the bookies believe the greater squad depth and financial resources of Chelsea and Manchester City will eventually see the big-spending giants fight out this year's crown.
The Blues are currently in second place - two points adrift of Arsenal - while Manchester City are one point further behind in fourth place.
But heading into the weekend and City - the 2012 English champions - were the $2.75 favourites at bet365 to win this season's title while Chelsea - the 2005, 2006 and 2010 league champions - were paying $3.75, with Arsenal on the third line of betting at $6.
As for Sunday's huge encounter at Stamford Bridge, Chelsea are the $2.30 favourites with bet365 compared to City at $3.20 and the draw at $3.40.
The pair met a staggering four times last season - including in the pre-season Community Shield - and City won three while the only meeting at Stamford Bridge ended in a draw.
But Chelsea's home record under manager Jose Mourinho - who led the club to the 2005 and 2006 titles in his first stint before joining the club again this season - is extraordinary.
They have never been beaten at home in a league match at Stamford Bridge under Mourinho while across all his clubs - Porto, Chelsea, Inter Milan and Real Madrid - Mourinho has lost just three of his past 197 home matches in league competitions.
And there are signs Chelsea are beginning to hit top form after an impressive 3-0 win away to German side Schalke in the Champions League in midweek meaning they are now unbeaten in their past seven matches in all competitions.
City, under their new manager Manuel Pellegrini, have also won their past three matches - including a 2-0 win away to CSKA Moscow in midweek.
But City have looked shaky away from home in the EPL so far this season - losing to Cardiff and Villa already and drawing at Hull.
And while a 1-1 draw is the clear favoured option in correct score betting at bet365 - at odds of $7 - Chelsea look the way to go in this big game and they are paying the same odds of $10 to win by either 1-0 or 2-1.
As for the goalscorer's markets, Fernando Torres - who looked right back to his best with two goals in midweek against Schalke - is well worth a bet at $3 with bet365 to score at any time and $7.50 to score the game's opening goal.
The other big game on Sunday is the Tyne/Wear derby between Sunderland and Newcastle.
The Black Cats are last on the table with just one point from eight games and the last team to avoid relegation from that position was Southampton in the 1998-99 season.
But buoyed by the arrival of new manager Gus Poyet, the Black Cats are virtually equal favourites for this game at $2.80 with bet365 compared to $2.60 for Newcastle while the draw is a tempting $3.30.
However the best bet in this game is to back on there being more than 2.5 goals scored in the match at $1.85 with bet365.
Newcastle have scored at least two goals in seven of their past eight games, while Sunderland are desperate for a win and will have to attack, while there has not been a goalless draw between these teams since 1989.
As a result we fancy a 2-2 draw at the massive odds of $13 with bet365.
In the other two games on Sunday, Swansea and Tottenham should both win at home despite a short preparation after playing in the Europa League on Thursday night.
The Swans are $1.72 with bet365 at home to West Ham at $5 - with the draw paying $3.75 - while Spurs are even shorter at $1.44 against newly promoted Hull at $7.50.
*Note prices subject to change