Heart and Victory could struggle away to Adelaide and at home to the Mariners respectively this weekend, while Sydney could spring a surprise away at Suncorp Stadium
Twice A-League champions, the Victory began the season as third favourites to win this season's grand final at bet365 behind last year's grand finalists Central Coast and Western Sydney.
But they were disappointing in the opening round last week in being held to 0-0 bore draw by Melbourne Heart.
And the Victory's preparations for the tough trip to Adelaide have not been helped by the suspension of their marquee players in central defender Pablo Contreras.
In contrast Adelaide have few worries and looked impressive, in their first match under new coach Josep Gombau, in beating Perth 3-1 last week.
Gombau, a former youth team coach at Spanish heavyweights Barcelona, looks to have bought their impressive passing style game to Adelaide after the Reds' third goal against the Glory came after a stylish 11-pass play.
The Reds, who firmed from $13 into $9 to win the grand final at bet365 after their impressive opening round performance, are the $2.37 favourites to win Friday night's clash at Hindmarsh.
The Victory are the $2.87 outsiders, with the draw paying $3.40 at bet365.
Adelaide have won five of their past eight matches against Melbourne, as well as drawing another two in that period, and lost just four times at home last season.
With the A-League's best keeper in goal in skipper Eugene Galekovic in goal, we think Adelaide to keep a clean sheet should be the basis of betting in this match.
The Reds look great value to win 1-0 at odds of $9.50 at bet365 in correct score betting while they look a safe bet at $1.72 in the draw no bet market - where punters get their money back if the game ends in a draw.
There are two games on Saturday and reigning champions Central Coast look a good bet at $2.20 at bet365 to win the first of them - away to Melbourne Heart at $3.20 while the draw is paying $3.40.
The Mariners played out a thrilling 1-1 draw with Western Sydney in the grand final re-match last week while the Heart showed little by way of attacking instinct during last week's 0-0 draw against the Victory.
In nine meetings between these sides the Mariners have won seven while one has been drawn and they do look the bet of the round.
In the other game on Saturday, Brisbane Roar are surprisingly short-priced favourites at $1.60 with bet365 at home against Sydney FC at $5.75 - with the draw paying $3.80.
Both teams recorded impressive first round wins with Sydney superstar Alessandro Del Piero again getting on the scoresheet in his team's 2-0 win over Newcastle.
The Sky Blues could be worth a punt at $4 in the draw no bet market - where punters get their money back if the game ends in a draw - with a 1-1 draw the equal favourite in correct score betting at odds of $7, the same price as the Roar are to win 1-0.
However it should be noted that the home side has won this fixture in the last five meetings between these sides.
*Note prices subject to change